The drug "Metadoxil": instructions for use, analogues, reviews

Unfortunately, liver problems that occur when exposed to high doses of ethyl alcohol, today can hardly be considered a rarity. And an important step in the treatment of alcoholism is the restoration and protection of the body. For this purpose, often used the tool "Metadoxyl". Instructions for its use are quite simple, side effects are rare, and the cost of the drug is relatively affordable. So what are the properties of this tool?

The composition and form of the drug release

drug metadoxil

Many patients and their relatives are interested in additional information about the drug "Metadoxyl". Instructions for use, analogues, contraindications, properties and side effects - these are extremely important issues. But it's worth starting with a description of the composition of the medicine

This tool is available in the form of tablets and solutions for injection.The pharmacy can buy round, biconvex tablets of white color. The main component of the drug is metadoxine (L-2 pyrrolidone 5-carboxylate). Microcrystalline cellulose and magnesium stearate are used as auxiliary substances in the manufacture. The tablets are placed in convenient blisters of 10 pieces.

In addition, your doctor may prescribe a drug for intravenous administration. The solution is clear, with almost no color and smell, only sometimes has a slightly yellowish tint. The drug is available in 5 ml ampoules of dark glass. The active ingredient here is the same - metadoxine. Sodium edetate, purified water for injection, as well as sodium metabisulfite and methyl parahydroxybenzoate are present as excipients.

Basic pharmacological properties

This medicine has pronounced hepatoprotective properties. The active ingredient of the drug restores the normal ratio of unsaturated and saturated free fatty acids, which, accordingly, stabilizes the membrane of liver cells. In addition, hepatocytes become less susceptible to lipid oxidation reactions that occur with toxic damage to the human body.

metadoxil instruction

The drug also provides a detoxification effect, as it activates certain liver enzymes, including acetaldehyde and aldehyde. These biologically active substances are responsible for the metabolism of ethanol in the body, and the increase in their activity, respectively, ensures the elimination of alcohol metabolites from the body, facilitating the patient's condition.

The drug also prevents the formation of collagen, fibronectin and other fibers in the liver, thus slowing down the development of cirrhosis. With severe hangover, the drug reduces the intensity of somatic and mental manifestations. In addition, metadoxil reduces the time required to relieve withdrawal symptoms.

It is also proven that the drug acts as a mild antidepressant and reduces craving for alcohol. In addition, it prevents the emergence of motor arousal, which is characteristic of the state of alcohol intoxication.

After taking the pill, the active components of the drug are quickly absorbed in the digestive tract. Bioavailability of the drug is 60-80%.Approximately 50% of the active substance is bound to plasma proteins. The metabolism of this tool occurs in the tissues of the liver. Approximately 50% is excreted with the urine within 24 hours after ingestion, and the rest - along with feces over the next four days.

Indications for use of the drug

metadoxil indications

In which cases, patients prescribed the drug "Metadoxil"? Indications for use here are as follows:

It is also worth noting that today this medicine is increasingly used as part of therapy in the presence of liver diseases that are not related to alcohol intoxication - in such cases, this tool also proved to be quite effective. Some also use the drug "Metadoxil" to combat hangover. But in no case should you take the medicine without authorization - a medical examination and medical consultation are obligatory in this case.

Drug "Metadoxil": instructions for use

Before treatment, a medical examination is required. Only a specialist after a thorough diagnosis can prescribe the drug "Metadoxil".Instructions for use in this case depends on the problem of the patient, his age, individual physiological features, as well as the severity of his condition.

metadoxil instructions for use

In acute alcohol intoxication of the body, as a rule, use a solution of the drug. Intramuscularly, 5-10 ml is administered to the patient. Intravenous administration is also possible in a volume of 5-15 ml. For an intravenous infusion, the required dose of the drug must be diluted in 500 ml of sodium chloride solution (5% dextrose solution can be used). The prepared medicine is administered with a dropper for 1.5 hours.

Intravenous infusions are also necessary for alcohol withdrawal syndrome. In such cases, the patient is administered 15 ml of the drug (previously diluted) once a day. The duration of therapy is 3-7 days depending on the severity of the person’s condition.

Metadoxyl tablets are used to treat liver damage, as well as in chronic alcoholism. The patient is recommended to take one tablet twice a day, preferably half an hour before meals. Duration of treatment is not less than 90 days.

Are there any contraindications?

Are there any contraindications to the use of the drug "Metadoxyl"? The instruction indicates that there are not so many of them. First of all, it is worth noting that the drug is not prescribed to people with hypersensitivity to any of the components. Absolute contraindications also include the period of pregnancy and breastfeeding.

The drug is prescribed with caution to people with Parkinson's disease. Therapy of patients suffering from bronchial asthma should be carried out under the strict supervision of medical personnel.

What side effects can a medicine cause?

metadoxil instruction reviews

Of course, this drug is considered effective and practically harmless. Nevertheless, many patients are interested in the question of what kind of adverse reactions can therapy with the help of the drug "Metadoxil". Instructions for use suggests that complications during treatment are extremely rare.

In most cases, side effects are associated with a particular type of allergy to the constituent components of a drug.Some patients have skin reactions that are accompanied by the appearance of rash, edema, itching, urticaria. The risk group can only be attributed to people diagnosed with "bronchial asthma", as in this case, if the medication is not used correctly (especially if it comes to intravenous administration) there is a risk of developing bronchospasm.

How much is the drug?

Today, many patients are interested in the question of what is the drug "Metadoxil". Instructions, reviews, indications and contraindications for use are also of interest. But an equally important factor is the cost of the medicine.

Naturally, the price may vary depending on various factors, including the manufacturer of the drug, as well as the pricing policy of the pharmacy. Nevertheless, an average of 10 ampoules of solution will cost 500-600 rubles. But the pills are a bit more expensive - 30 pieces cost about 1,300-1400 rubles.

Drug "Metadoxyl": analogues

metadoxil analogues

Unfortunately, for one reason or another, this medicine is not suitable for every patient. So is it possible to replace Metadoxyl with something? Analogs of this drug, of course, exist.

For example, the drug Vocacyte is considered to be a rather effective substitute, which is available in powder form for the independent preparation of suspensions. Well proven and drops "Kolme". The list of analogues can also be attributed to "Deltaran", "Proproten", "Medihronal" and "Cyamide". But in any case, first it is better to consult a doctor, as only a specialist can recommend a really suitable medicine. Self-medication can only aggravate the situation, so you should not risk health.

Reviews of doctors and patients about the drug

Today, many patients experiencing problems with alcohol, it uses the tool "Metadoxil." Reviews about it are mostly positive. People say that the medicine really helps to quickly get rid of the hangover syndrome and improves well-being. Moreover, the drug allows you to speed up the process of recovery of the liver and reduces physical craving for alcohol. The undoubted advantage is the minimum number of contraindications and side effects.

metadoxil reviews

What do doctors say about the drug "Metadoxil"? Feedback from specialists is also mostly positive.Naturally, the drug is not a panacea that can heal the body or cure from alcoholism. Nevertheless, the rehabilitation process is indeed accelerated during medication.

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