When alanine aminotransferase is increased or decreased, what are the correction methods?
Alanine aminotransferase is an enzyme from the group of transferases that is involved in the metabolism of amino acids. It is found in large quantities in the cells of the heart, kidneys and liver, as well as in skeletal muscle. In the blood of this enzyme is missing or is in very small quantities. It is the main indicator of cytolysis, so the determination of its amount in the blood makes it possible to judge the damage to the corresponding internal organs.
Alanine aminotransferase: normal
The level of this compound in serum depends on age and gender. Thus, for women, the concentration of ALT should be no more than 31 units / l, for men - no more than 41. In children, in the first 5 days of life, the level of alanine aminotransferase reaches 49 units / l, and by 6 months of age it increases to 56. In children 3 6 years ALT is not more than 29.
Alanine aminotransferase increased: causes
An increase in the amount of this enzyme in the blood indicates the following pathologies:
• viral hepatitis;
• oncoprocess in the liver or the effect of toxic compounds on the organ, including alcohol;
• alanine aminotransferase increased with drug intoxication;
• heart failure, other heart damage (for example, myocarditis or heart attack);
• shock that develops on the background of severe injuries or massive burns;
• necrotic process in skeletal muscle.
Other etiological factors
As a rule, alanine aminotransferase is elevated in acute pancreatitis, lymphoblastic leukemia, liver steatosis or in infectious mononucleosis. Quite often, the level of this hormone increases in the second trimester of pregnancy. With mechanical or obstructive jaundice, its concentration in the blood also increases. It is worth noting that the blood test for ALT is carried out with the simultaneous determination of the level of AST. The ratio of these two indicators allows you to more clearly determine the localization of the pathological process and its severity.
Alanine aminotransferase reduced: causes
The amount of ALT decreases with infections in the organs of the urogenital system, oncopathology of various etiologies, diseases of the pancreas, with a lack of pyridoxal phosphate, which can occur with poor diet or frequent use of alcoholic beverages. In addition, a low level of ALT is associated with severe liver disease, when a large number of hepatocytes that synthesize this hormone are destroyed.
If alanine aminotransferase is increased, treatment must necessarily include the elimination of the etiological factor that caused this violation. Thus, the main pathology is treated, choleretic drugs, hepatoprotectors, as well as agents that improve digestion are additionally prescribed. If the increase in ALT is due to the intake of individual drugs, then consider the possibility of using their analogues, which do not affect the level of this enzyme. It should be noted that the level of alanine aminotransferase is an important biochemical indicator, since it speaks of serious diseases of the internal organs, which with timely therapy can have a favorable prognosis.