"Zofloks": instructions for use, price, analogues and reviews

From the middle of the 20th century, a new group of drugs created on the basis of unusual substances synthesized by various microorganisms began to appear in the practice of doctors. Subsequently, they were called antibiotics, since it was noticed that such compounds have pronounced antimicrobial activity and are able to inhibit the growth of pathological flora, which is the main cause of the occurrence of inflammatory conditions of the body.

Antimicrobial Assistants

Today it is a large group of chemotherapeutic drugs, obtained in both natural and synthetic ways.

zoflox instructions for use

They have the property of bactericidal and static with a special ability to destroy or slow down the growth of the antagonistic microorganisms surrounding them.

Antibiotics selectively affect certain types of bacteria and protozoa, leaving intact cells and symbiotic flora of the microorganism. In this regard, isolated such a thing as the spectrum of the antibiotic.It is narrow or wide, indicating the possibility of the suppression of a particular group of microorganisms.

The need for antibiotics

In medicine, antibiotics are the most diverse group of therapeutic drugs. Their use is justified in the event of septic inflammation caused by the vital activity of pathogenic microflora.

Of course, the body has its own system of protection against foreign agents, represented by immunity. However, it can also be powerless when confronted with especially dangerous infections, high virulence of the pathogen or when it is massively injected into the body.

Zoflox 400 instruction

It is here that antibiotic drugs come to the rescue, often saving health and human life from imminent death during the invasion of pathogenic agents. After all, even a simple sore throat can cause serious complications or death in the absence of adequate treatment.

Second Generation Fluoroquinolones

One of them is the drug "Zofloks", instructions for use and the characteristic properties of which will be presented in detail below.

zoflox instructions for use

Another common name of the drug is "Ofloxacin", after the name of the main active ingredient, which belongs to the group of fluoroquinolones.These drugs have great experience in medical practice. They are distinguished from other antibiotic groups by a characteristic, fundamentally special, mechanism of action on pathogenic microorganisms. Due to this, they are effectively used even with infections caused by multi-resistant strains of bacteria.

zoflox instruction manual

The drug "Zofloks", whose analogues have the same mechanism of action, works as follows when it encounters an infection.

The process of the death of a microbe develops by blocking the formation of DNA in the body of the pathogen by inhibiting the work of the most important enzymes involved in this process. The spectrum of exposure to microbial groups is wide.

There are several generations of fluoroquinolone drugs. The substance ofloxacin belongs to the second generation of such agents. Accordingly, it can be said about the drug "Zofloks".

Exposure spectrum

The drug effectively affects gram-negative microorganisms: the group of Escherichia coli, pathogens of salmonellosis, shigellosis, yersiniosis, gonorrhea, legionellosis, chlamydia, mycoplasmosis, meningitis, nosocomial infections caused by Proteus,Morgan bacterium, hemophilus bacillus, pneumonia caused by Klebsiela, intestinal disorders with enterobacter and other saprophytic flora.

zoflox instructions for use

Gram-positive flora, also susceptible to the effects of a substance such as Zofloks, is mainly represented by staphylo-and streptococcal bacteria. Resistance to the drug was found in pseudomonads, enterobacter fecalis, streptococcus pneumonia, as well as in anaerobes.

A significant feature is the activity against beta-lactamase produced by many infections as a protective factor against the destruction of drugs. The antibiotic "Zofloks" is resistant to the effects of this factor, therefore, it is successfully able to be used also for diseases caused by such pathogens.

Zofloks Tablets, composition and dosage

The main form of release drugs are coated tablets.

According to the pharmacotherapeutic group, the drug is an antimicrobial agent that acts on the body systemically, is included in the subgroup of quinoline antibiotics.

Physical and chemical characteristics are described which have tablets "Zofloks",instruction which presents them as capsule-shaped, convex on both sides. Usually they are coated with white or whitish colors.

By composition1 tablet "Zofloks-400" includes ofloxacin 400 mg.

Other components that form the volume are lactose, starch, magnesium stearate and other chemical compounds.

The surface shell contains titanium dioxide, talc, hydroxypropyl methylcellulose, polyethylene glycol.

There is a different dosage of the Zoflox tablet - 200 mg, which makes it more convenient to titrate the concentration if necessary to correct the treatment.

Pharmacokinetic features of the drug

When taken orally, sufficient medication quickly and easily enters the bloodstream from the lumen of the gastrointestinal tract. Food slows down the process of adsorption of quinolones, while not significantly affecting the bioavailability of the substance. The peak concentration of ofloxacin in the blood is observed after 1-2 hours. Availability reaches 96-100%.

When distributed approximately 25% bound to plasma transport proteins. Ofloxacin is able to leak through the placental barrier and into the milk during lactation, which should be strictly taken into account when prescribing the drug "Zofloks" (analogues have the same features) for pregnant and lactating women.

Only a small part of the drug is metabolized, only up to 5% of ofloxacin. The elimination time ranges from approximately 5 to 8 hours. About 80% of the drug "Zofloks" excreted through the kidneys in unmetabolized form, creating a high level of it in the urine.

In patients with renal and hepatic pathology, the release of ofloxacin from the body can be somewhat slow, which will require the mandatory adjustment of the amount of the drug to reduce the risk of negative reactions and overdose.

The list of main indications for the appointment of the drug

The drug "Zofloks", instructions for use of which is described in detail, is assigned in many clinical situations. Diseases caused by microbial agents are very diverse. They are represented by the following types of violations:

  • Inflammatory processes affecting the lower respiratory tract (pneumonia).
  • Infectious diseases of the ears, throat, nasal cavity (pharyngitis, otitis, laryngitis, inflammation of the tracheal mucosa).
  • Diseases of the skin and musculoskeletal system associated with microbial flora (abscess, furunculosis, purulent arthritis).
  • Infectious-inflammatory processes of the abdominal cavity and pelvic organs.
  • Diseases of the kidneys and pelvic organs, including sexually transmitted diseases (inflammation of the prostatic gland, bladder, gonorrhea, chlamydial infection).

Application of "Zofloksa"should be carried out strictly according to indications. Moreover, the dose of the drug also depends on the localization of the infectious process.

Dosage and regimens

antibiotic zofloks

The purpose of the drug is carried out only for adults and children over 14 years of age. The maximum possible dose per day is limited to 800 mg.

The average adult daily dosage is 200-400 mg, taken twice a day. For patients with pathology on the part of the excretory system with reduced kidney function, the limit is achieved by taking 200 mg daily.

The duration of taking the drug from a week to 10 days. Upon request, the course of therapy can be lengthened while under medical supervision. It is advised not to use this medicine for more than 2 months.

As with any other antibiotic, including Zofloks, the instructions for use recommend taking the drug half an hour before meals, reducing the risk of the drug breaking down with the hydrochloric acid of the stomach secreted by eating food.Wash down should be a small amount of simple boiled water, excluding tea, juice and other aggressive liquids. With a pass in the admission and violation of the treatment regimen, a single daily allowance is possible.

BelowThe approximate dosages of the drug "Zofloks 400" are given, the administration of which is designed for typical clinical situations:

  • When inflammation of the respiratory tract is prescribed 400 mg of the drug per day with a margin of dose increase to 400 mg 2 times.
  • Infectious ENT diseases will require receiving 200 mg 2 times a day.
  • Pathology of the skin and the supporting system responds to a dose of 400 mg 2 times a day.
  • Violations of the genital organs are treated with medication 400 mg twice a day.
  • Hemodialysis patients are prescribed 100-200 mg of the drug once a day.

Body reactions to treatment

The drug is well tolerated, but side effects cannot be ruled out. Manifestations of extraneous reactions from the stomach-intestine system consist in the occurrence of nausea, loss of appetite, diarrhea, and gagging.

On the part of the nervous system, headache, weakness, increased desire to sleep, blurred vision and taste sensations may disturb.Allergic and immunity reactions are very rare, but still possible by the type of skin rash, angioedema, shock.

zoflox application

Blood can react with anemia, leukopenia, neutropenia, thrombocytopenia. The cardiovascular system can respond with the development of rapid heartbeat and a drop in blood pressure.

Drug is contraindicatedwith hypersensitivity to the group of fluoroquinolones, epileptic predisposition, pregnancy, lactation, as well as in children under 14 years of age.

Features of the use of the drug "Zofloks", the instructions for use of which this indicates, are in a careful and balanced approach if the patient has atherosclerotic lesion of cerebral vessels, with circulatory disorders in the nervous system, with altered kidney performance. Exposure to the ultraviolet spectrum of solar radiation should be excluded due to the likelihood of skin reactions even within a week after the withdrawal of the agent.

When taken in parallel with antacid drugs, a decrease in the effectiveness of the antibiotic Zofloks is observed,as a result, it is recommended to take them separately with an interval of 2-6 hours after the first use, as well as drugs containing zinc, bismuth or iron.

The high probability of developing convulsive syndrome prevents the simultaneous use of the antibiotic of the fluoroquinolone group with non-steroidal anti-inflammatory drugs due to excessive excitation of the central nervous system.

You can not use the drug "Zofloks", its type analogues and any other drugs with an expired date.

During the period of antibiotic use, it is necessary to observe the optimal water regime (1.2-1.5 l / day).

The drug "Zofloks" and alcohol - two mutually exclusive concepts. During the period of taking the antibiotic it is recommended to refrain from taking it because of the high risk of severe liver damage.

Excess drug use

Busting by the patient or improper selection of the dose of the drug can cause abdominal disorders such as diarrhea, painful spasms, nausea and vomiting, as well as cerebral symptoms of poisoning in the form of headache, agitation, dizziness.

Interstitial nephritis is a rarer but possible complication of drug overdose.

To assist, detoxification is performed in the form of gastric lavage and rehydration therapy, as well as effects on symptoms.

Antifungal drugs can be prescribed by a specialist to prevent the development of dysbiosis, which is a frequent companion for long-term antimicrobial drug therapy.

Also, in parallel with taking an antibiotic, it is recommended to add drugs that restore the normal intestinal flora, since it is known that lactic acid bacteria die under the influence of aggressive antibacterial drugs, which should be considered in order not to harm people.

Price and analogues

On average, the cost of the drug tableted Zofloks with a dosage of 200 mg or 400 mg ranges from 190 to 220 rubles per pack.

Analogues of the drug are antibiotics "Danzil", "Glaufos", "Zanotsin", "Geofloks", "Ofloksabol", "Tarivid", "Taritsin", "Floksal", "Tariferid", "Unifloks" and others, based on ofloxacin.

Zoflox 400 instruction

Patient Reviews

Pro drug "Zofloks" reviews about the reception are often found, especially in the treatment of chlamydial and pneumococcal infections,as well as about one of the components of combination therapy resistant to the effects of tuberculosis. In principle, this is his primary evidence before prescribing other antimicrobial agents. Tolerability of the antibiotic is different, and often not only one fluoroquinolone is required, but also a number of concomitant pathogenetically based drugs. Therefore, taking into account not only the description of such a drug as Zofloks, patient reviews are also sometimes negative, it is necessary to comprehensively and comprehensively study the problem. Sometimes additional diagnostic measures are sufficient to determine the estimated efficacy of a drug, which will significantly improve its performance and leave a pleasant impression of its reception in a cured patient.

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